Experimental pancreatic diabetes animals is accompanied by the excessive hunger or polyphagia diabetes melitus in man. Dr. Luckhardt studied the gastric hun contractions in two dogs during the entire course of fatal pancrei diabetes. With good care dogs live from 4 to 6 weeks after compl pancreatectomy, showing progressive emaciation despite their exc sive intake of food. Tn both the diabetic dogs the gastric ten and hunger contractions were more continuous and vigorous tl in normal dogs or in the same dogs before they became diabel This augmentation of the gastric hunger contractions persisted till within 24 hours of the death of the animals, despite the progx sive and finally extreme emaciation and weakness. The increas food consumption of the dogs thus ran parallel with the grea vigor of the peripheral hunger mechanism. And there can be lit doubt that the dogs felt greater hunger and consumed more fc because of the greater vigor of the gastric hunger contractions.
The cause of this augmented contraction of the empty stoxns in diabetes is still an open question. .It is evidently due, at le in part, to some change in the blood, for transfusion of diabe blo<xl into normal dogs stimulates the hunger contractions in t latter. Allen states that when partial diabetes in man is control by means of temporary starvation and dieting, so that the uri becomes free from sugar and the acidosis disappears, the polyphaj of the diabetic patient also disappears, but we do not know whetl the latter is due to a return of the gastric hunger mechanism to 1 normal state of activity.