Syphilitic ulcers are often referred to as undergoing malignant degeneration, but the condition is certainly unusual. The change may take place either in an ulcer or in the scar produced by suchan ulcer, usually the latter. In the former instance it is noted that the granulation tissue becomes raised at some point, and that it bleeds very readily. The tissue is friable, and is slightly paler than the rest of the granulations. Induration may be felt around the edges. The further course shows either a deeply eating ulcer or a fungous growth, or a combination of the two. These lesions are usually of the more malignant type, and hence demand extensive operative interference.

*Gottheil: Jour. Amer. Med. Assn., 1912, lvix, 14.

*Dubreuilh and Petges: Ann. de dermat. et de syphil., 1909, x, 106.

*Janeway: Jour. Cutan. Dis., 1910, xxviii, 140.

*Bloodgood: Progressive Medicine, Dec, 1907.

*Bloodgood: Progressive Medicine, Dec, 1904.