Chronic leg ulcers rarely become cancerous. Both Bloodgood* and Gottheil* have noted this, the former having seen but three cases, and the latter having been able to collect but ten cases from the literature. Most dermatologists and surgeons express surprise that such a change does not take place more frequently, but to the author it does not seem surprising when one considers that cancer prefers to originate from a dry sore and not from a moist one. In common with most carcinomata of the extremities, these growths are usually of the spinous-celled type and hence are very malignant. Operation should consist of wide local removal, the glands likewise being taken out. Amputation is frequently necessary. In the case illustrated in Fig. 30 the growth was curetted and excised, and thoroughly cauterized with acid nitrate of mercury, and has escaped recurrence for three years.