The average weight of the spleen in our male cases was 5 oz., and in our female cases 4.2 oz. Since its normal weight varies up to 10 oz., it is obvious that the organ is considerably reduced in size in malignant disease of the stomach. The atrophy is most marked when the orifices of the stomach are the seat of the new growth. Thus, its average weight was 3.8 oz. when the cardiac orifice was affected, 6.2 oz. in disease of the body of the viscus, and 4.6 oz. when the pylorus was implicated. Infarction occurred in about 2 per cent, of the cases, and in 3.7 per cent, the organ was the seat of metastases.